Over the last 15 years, an increasing amount of evidence has accumulated showing that the innate immune system also has features of a memory. The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the severity of infectious diseases. 3Institute for Infectious Disease and Infection Control, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.2Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.1Instituto Gulbenkian de Ciência, Inflammation Laboratory, Oeiras, Portugal.Elisa Jentho 1,2* and Sebastian Weis 2,3*